GUINEAS winner Kameko will not head to Ascot for the QEII on Saturday.
Connections will instead eye a trip to the States for a Breeders' Cup bid.
It leaves the John Gosden-trained Palace Pier as the 8-13 strong favourite for the mile showpiece.
Trainer Andrew Balding has enjoyed a terrific season with his stable star Kameko, but the team felt conditions would be too testing.
The Breeders' Cup Mile on November 7 at Keeneland is on their agenda, for which Betway made him the 3-1 favourite.
David Redvers, racing manager for owners Qatar Racing, said: "Given the ground at Ascot is going to be testing, Kameko will go straight to the Breeders' Cup and will not run on Saturday."
Coral's David Stevens said: "Connections of Kameko had warned earlier this week that the Guineas winner may not line up at Ascot on soft ground.
"And as a result Palace Pier had already been backed into 4-6 favourite for the Queen Elizabeth II Stakes, and with his major rival now a confirmed absentee, the latter is now 8-13 to maintain his unbeaten record."
QEII BETWAY MARKET
Palace Pier 4-7
The Revenant 4-1
Circus Maximus 8-1
Century Dream 16-1
Lord Glitters 20-1
FULL BETWAY MARKET & LATEST ODDS
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